Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents

Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents

Considerable efforts have been focused on the exploitation of macromolecule ligands for synthesis of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles as <i>T</i><sub>1</sub> magnetic resonance imaging (MRI) contrast agents, but studies that concern m...

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Main Authors: Cheng Tao, Yanan Chen, Danli Wang, Yu Cai, Qiang Zheng, Lu An, Jiaomin Lin, Qiwei Tian, Shiping Yang
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Nanomaterials
Subjects:
<i>T</i><sub>1</sub>-weight contrasts
iron oxide
surface charge
coprecipitation synthesis
MRI
Online Access:https://www.mdpi.com/2079-4991/9/5/699
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record_format Article
collection DOAJ
language English
format Article
sources DOAJ
author Cheng Tao
Yanan Chen
Danli Wang
Yu Cai
Qiang Zheng
Lu An
Jiaomin Lin
Qiwei Tian
Shiping Yang
spellingShingle Cheng Tao
Yanan Chen
Danli Wang
Yu Cai
Qiang Zheng
Lu An
Jiaomin Lin
Qiwei Tian
Shiping Yang
Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents
Nanomaterials
<i>T</i><sub>1</sub>-weight contrasts
iron oxide
surface charge
coprecipitation synthesis
MRI
author_facet Cheng Tao
Yanan Chen
Danli Wang
Yu Cai
Qiang Zheng
Lu An
Jiaomin Lin
Qiwei Tian
Shiping Yang
author_sort Cheng Tao
title Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents
title_short Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents
title_full Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents
title_fullStr Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents
title_full_unstemmed Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast Agents
title_sort macromolecules with different charges, lengths, and coordination groups for the coprecipitation synthesis of magnetic iron oxide nanoparticles as <i>t</i><sub>1</sub> mri contrast agents
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2019-05-01
description Considerable efforts have been focused on the exploitation of macromolecule ligands for synthesis of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles as <i>T</i><sub>1</sub> magnetic resonance imaging (MRI) contrast agents, but studies that concern macromolecule ligands with different charges and coordination groups are still limited. Herein, we used poly(acrylic acid) (PAA), poly(allylamine hydrochloride) (PAH), and polyvinyl alcohol (PVA), which possess negative, positive and neutral charges with carboxylic acid, amino and hydroxyl groups respectively, as templates and stabilizers to fabricate Fe<sub>3</sub>O<sub>4</sub> nanoparticles through coprecipitation reaction. The obtained Fe<sub>3</sub>O<sub>4</sub>-PAA, Fe<sub>3</sub>O<sub>4</sub>-PAH, and Fe<sub>3</sub>O<sub>4</sub>-PVA nanoparticles showed <i>T</i><sub>1</sub> contrast performance with <i>r</i><sub>1</sub> relaxivities of 23.4, 60.3, and 30.6 mM s<sup>&#8722;1</sup> at 0.5 T (25 &#176;C), and a <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio of 2.62, 3.82, and 7.26, respectively. The cell viability assay revealed that Fe<sub>3</sub>O<sub>4</sub>-PAA and Fe<sub>3</sub>O<sub>4</sub>-PVA exhibited good biocompatibility, while Fe<sub>3</sub>O<sub>4</sub>-PAH displayed high cytotoxicity. In vivo <i>T</i><sub>1</sub>-weighted (1 T) mice showed that both Fe<sub>3</sub>O<sub>4</sub>-PAA and Fe<sub>3</sub>O<sub>4</sub>-PVA were able to display remarkably brighten the contrast enhancement for the mice tumor and kidney sites, but Fe<sub>3</sub>O<sub>4</sub>-PAA had better contrast performance. This work highlights that the macromolecule ligands play an important role in the biocompatibility and <i>T</i><sub>1</sub> contrast performance of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles.
topic <i>T</i><sub>1</sub>-weight contrasts
iron oxide
surface charge
coprecipitation synthesis
MRI
url https://www.mdpi.com/2079-4991/9/5/699
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spelling doaj-b7932cbc936f44368916239cb4707ef02020-11-25T02:07:04ZengMDPI AGNanomaterials2079-49912019-05-019569910.3390/nano9050699nano9050699Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as <i>T</i><sub>1</sub> MRI Contrast AgentsCheng Tao0Yanan Chen1Danli Wang2Yu Cai3Qiang Zheng4Lu An5Jiaomin Lin6Qiwei Tian7Shiping Yang8The Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, and The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaConsiderable efforts have been focused on the exploitation of macromolecule ligands for synthesis of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles as <i>T</i><sub>1</sub> magnetic resonance imaging (MRI) contrast agents, but studies that concern macromolecule ligands with different charges and coordination groups are still limited. Herein, we used poly(acrylic acid) (PAA), poly(allylamine hydrochloride) (PAH), and polyvinyl alcohol (PVA), which possess negative, positive and neutral charges with carboxylic acid, amino and hydroxyl groups respectively, as templates and stabilizers to fabricate Fe<sub>3</sub>O<sub>4</sub> nanoparticles through coprecipitation reaction. The obtained Fe<sub>3</sub>O<sub>4</sub>-PAA, Fe<sub>3</sub>O<sub>4</sub>-PAH, and Fe<sub>3</sub>O<sub>4</sub>-PVA nanoparticles showed <i>T</i><sub>1</sub> contrast performance with <i>r</i><sub>1</sub> relaxivities of 23.4, 60.3, and 30.6 mM s<sup>&#8722;1</sup> at 0.5 T (25 &#176;C), and a <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio of 2.62, 3.82, and 7.26, respectively. The cell viability assay revealed that Fe<sub>3</sub>O<sub>4</sub>-PAA and Fe<sub>3</sub>O<sub>4</sub>-PVA exhibited good biocompatibility, while Fe<sub>3</sub>O<sub>4</sub>-PAH displayed high cytotoxicity. In vivo <i>T</i><sub>1</sub>-weighted (1 T) mice showed that both Fe<sub>3</sub>O<sub>4</sub>-PAA and Fe<sub>3</sub>O<sub>4</sub>-PVA were able to display remarkably brighten the contrast enhancement for the mice tumor and kidney sites, but Fe<sub>3</sub>O<sub>4</sub>-PAA had better contrast performance. This work highlights that the macromolecule ligands play an important role in the biocompatibility and <i>T</i><sub>1</sub> contrast performance of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles.https://www.mdpi.com/2079-4991/9/5/699<i>T</i><sub>1</sub>-weight contrastsiron oxidesurface chargecoprecipitation synthesisMRI

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