A biosensor based on a modified S-taper fiber for target protein detection

• Main Authors: Xiaoqi Liu, Yange Liu, Zhi Wang
• Format: Article
• Language: English
• Published: AIP Publishing LLC 2020-09-01
• Series: Nanotechnology and Precision Engineering
• Subjects: Photonic crystal fibers; Biosensor; S-taper fiber; Immobilization process
• Online Access: http://www.sciencedirect.com/science/article/pii/S2589554020300258

A biosensor based on a modified S-taper fiber was proposed and experimentally demonstrated for antigen detection. Antibody was immobilized over the activated S-taper waist, where the fiber detected the interaction between the antibody and target antigen. Compared with a unmodified S-taper fiber structure, the silanized fiber had a detection limit of approximately 8.33 × 10−5 RIU when the concentration of antigen solution was changed 1%. The antibody and antigen binding processing was monitored in real time by analyzing and investigating the transmission spectral characteristics of the modified S-taper fiber. The cost-effectiveness, real-time detection, and high integration properties of the fiber enable its use in a modal interferometer for biosensing applications including disease diagnosis and biological specificity recognition.