1α,25(OH)2D3-glycosides from Solanum glaucophyllum leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation

1α,25(OH)2D3-glycosides from Solanum glaucophyllum leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation

We have previously shown that Solanum glaucophyllum leaf extract (SGE) increases VDR protein levels and promotes myoblast differentiation. Here, we investigated whether p38 MAPK and AKT are involved in SGE actions. Cell-cycle studies showed that SGE prompted a peak of S-phase followed by an arrest i...

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Bibliographic Details
Main Authors: Ana Paula Irazoqui, Pablo De Genaro, Claudia Buitrago, Heinrich Bachmann, Verónica González-Pardo, Ana Russo de Boland
Format: Article
Language:English
Published: The Company of Biologists 2018-05-01
Series:Biology Open
Subjects:
C2C12 cells
1α,25(OH)2D3-glycosides
P38 MAPK
AKT
MyoD1
Myogenin
MHC2b
Proliferation
Online Access:http://bio.biologists.org/content/7/5/bio033670

Internet

http://bio.biologists.org/content/7/5/bio033670

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