Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs

Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs

We developed an efficient, stereoselective synthetic method for the diketopiperazine moiety of neoechinulin A and its derivatives. The intramolecular cyclization at 80 ºC proceeded with minimal racemization of the stereogenic center at C-12 on neoechinulin A, even though the cyclization at 110 ºC ca...

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Bibliographic Details
Main Authors: Toshiaki Aoki, Kensuke Ohnishi, Masaaki Kimoto, Satoshi Fujieda, Kouji Kuramochi, Toshifumi Takeuchi, Atsuo Nakazaki, Nobuo Watanabe, Fumio Sugawara, Takao Arai, Susumu Kobayashi
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Pharmaceuticals
Subjects:
neoechinulin A
intramolecular cyclization
cytoprotective activity
Online Access:http://www.mdpi.com/1424-8247/3/4/1063/

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