GATA2−/− human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment

GATA2−/− human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment

Background: Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of hematopoiesis in mouse models. However, whether similar function of GATA2 is c...

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Bibliographic Details
Main Authors: Ke Huang, Juan Du, Ning Ma, Jiajun Liu, Pengfei Wu, Xiaoya Dong, Minghui Meng, Wenqian Wang, Xin Chen, Xi Shi, Qianyu Chen, Zhongzhou Yang, Shubin Chen, Jian Zhang, Yuhang Li, Wei Li, Yi Zheng, Jinglei Cai, Peng Li, Xiaofang Sun, Jinyong Wang, Duanqing Pei, Guangjin Pan
Format: Article
Language:English
Published: SpringerOpen 2015-01-01
Series:Cell Regeneration
Subjects:
hESCs
GATA2
EHT
HPC
Granulocyte
Notch signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S204597691730007X

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