Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, a...

Full description

Bibliographic Details
Main Authors: Nobuaki Egashira, Hikari Iba, Haruna Kuwano, Rikako Kawanaka, Masaki Nagao, Hiroshi Moriyama, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Kamishoyosan
Conditioned fear stress
Ovariectomized rats
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300895
Description
Summary:In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.
ISSN:1347-8613

Similar Items