High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

Abstract Tumors responding to immune checkpoint inhibitors (ICIs) have a higher level of immune infiltrates and/or an Interferon (IFN) signature indicative of a T-cell-inflamed phenotype. Melanoma and lung cancer demonstrate high response rates to ICIs and are commonly referred to as “hot tumors”. T...

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Bibliographic Details
Main Author: Saman Maleki Vareki
Format: Article
Language:English
Published: BMJ Publishing Group 2018-12-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Immunotherapy
Cancer
Checkpoint inhibitors
Hot and cold tumors
T-cell-inflamed and non-T-cell-inflamed tumors
High TMB and low TMB tumors
Online Access:http://link.springer.com/article/10.1186/s40425-018-0479-7

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http://link.springer.com/article/10.1186/s40425-018-0479-7

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