| Summary: | Surface-enhanced Raman scattering (SERS) is a promising technology owing to its single-molecular sensitivity and molecular specificity. However, producing strong and stable SERS signal from plasmonic nanostructures remains a challenge. Herein, we present a facile generation of SERS-active nanomaterials by organizing metallic nanoparticles onto dye-labeled three-dimensional DNA nanostructures. Stable formations of metal clusters with the dye located in hot spots enabled detection of SERS signals. SERS signals were further regulated via interaction of pyramidal DNA scaffold with target biomolecules. We believe our SERS-active nanomaterials with controllable geometry and reversible SERS effects meet significant requirements for practical SERS-based sensors. By integrating versatile properties of DNA and introducing various Raman dyes into plasmonic nanostructures, the emergence of powerful and multiplexed biosensors should be possible. Keywords: DNA nanostructures, Surface-enhanced Raman scattering, Plasmonic nanostructures, DNA pyramid
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