Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects

Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabeti...

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Main Authors: Huailong Bi, Dou Niu, Chen Guo, Jia Li, Xue Chen, Yuan Zhang, Shaojun Wang, Jiqing Bai, Xing Li, Jiefang Kang
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2019/3986964
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language English
format Article
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author Huailong Bi
Dou Niu
Chen Guo
Jia Li
Xue Chen
Yuan Zhang
Shaojun Wang
Jiqing Bai
Xing Li
Jiefang Kang
spellingShingle Huailong Bi
Dou Niu
Chen Guo
Jia Li
Xue Chen
Yuan Zhang
Shaojun Wang
Jiqing Bai
Xing Li
Jiefang Kang
Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
Evidence-Based Complementary and Alternative Medicine
author_facet Huailong Bi
Dou Niu
Chen Guo
Jia Li
Xue Chen
Yuan Zhang
Shaojun Wang
Jiqing Bai
Xing Li
Jiefang Kang
author_sort Huailong Bi
title Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
title_short Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
title_full Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
title_fullStr Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
title_full_unstemmed Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
title_sort comparative study of crude and wine-processing corni fructus on chemical composition and antidiabetic effects
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2019-01-01
description Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, sweroside, and cornuside by UPLC was developed, and validating crude and wine-processing CF was done for the first time. Mice were randomly divided into the following groups and orally given different solutions for 4 weeks: normal group (NC, 0.4% (w/v) CMC-Na), model group (DM, 0.4% (w/v) CMC-Na), crude CF group (CP, 3.87 g/kg), and wine-processing CF group (PP, 3.87 g/kg) followed by HFD and multiple subcutaneous injection of STZ (40 mg/kg) to induce the diabetes model except the NC group. Biochemical indexes (body weight, fasting blood glucose level, lipid level, insulin, and free fatty acid) and other parameters involving liver toxicity were measured with commercial kits and immunohistochemical method. Comparative studies on pharmacology showed that the crude extracts possess higher efficacy on hypoglycemia and hypolipidemia, while wine-processing products exhibit better effects on liver preservation. Our data suggested that wine processing was recommended when CF was used for protecting the liver; however, crude products should be used as antidiabetic drugs.
url http://dx.doi.org/10.1155/2019/3986964
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spelling doaj-b767b045077441b08ae7a29b2d081e172020-11-25T01:42:37ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/39869643986964Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic EffectsHuailong Bi0Dou Niu1Chen Guo2Jia Li3Xue Chen4Yuan Zhang5Shaojun Wang6Jiqing Bai7Xing Li8Jiefang Kang9Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaShaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaWine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, sweroside, and cornuside by UPLC was developed, and validating crude and wine-processing CF was done for the first time. Mice were randomly divided into the following groups and orally given different solutions for 4 weeks: normal group (NC, 0.4% (w/v) CMC-Na), model group (DM, 0.4% (w/v) CMC-Na), crude CF group (CP, 3.87 g/kg), and wine-processing CF group (PP, 3.87 g/kg) followed by HFD and multiple subcutaneous injection of STZ (40 mg/kg) to induce the diabetes model except the NC group. Biochemical indexes (body weight, fasting blood glucose level, lipid level, insulin, and free fatty acid) and other parameters involving liver toxicity were measured with commercial kits and immunohistochemical method. Comparative studies on pharmacology showed that the crude extracts possess higher efficacy on hypoglycemia and hypolipidemia, while wine-processing products exhibit better effects on liver preservation. Our data suggested that wine processing was recommended when CF was used for protecting the liver; however, crude products should be used as antidiabetic drugs.http://dx.doi.org/10.1155/2019/3986964