Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects
Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabeti...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2019-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2019/3986964 |
id |
doaj-b767b045077441b08ae7a29b2d081e17 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huailong Bi Dou Niu Chen Guo Jia Li Xue Chen Yuan Zhang Shaojun Wang Jiqing Bai Xing Li Jiefang Kang |
spellingShingle |
Huailong Bi Dou Niu Chen Guo Jia Li Xue Chen Yuan Zhang Shaojun Wang Jiqing Bai Xing Li Jiefang Kang Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects Evidence-Based Complementary and Alternative Medicine |
author_facet |
Huailong Bi Dou Niu Chen Guo Jia Li Xue Chen Yuan Zhang Shaojun Wang Jiqing Bai Xing Li Jiefang Kang |
author_sort |
Huailong Bi |
title |
Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects |
title_short |
Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects |
title_full |
Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects |
title_fullStr |
Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects |
title_full_unstemmed |
Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects |
title_sort |
comparative study of crude and wine-processing corni fructus on chemical composition and antidiabetic effects |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2019-01-01 |
description |
Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, sweroside, and cornuside by UPLC was developed, and validating crude and wine-processing CF was done for the first time. Mice were randomly divided into the following groups and orally given different solutions for 4 weeks: normal group (NC, 0.4% (w/v) CMC-Na), model group (DM, 0.4% (w/v) CMC-Na), crude CF group (CP, 3.87 g/kg), and wine-processing CF group (PP, 3.87 g/kg) followed by HFD and multiple subcutaneous injection of STZ (40 mg/kg) to induce the diabetes model except the NC group. Biochemical indexes (body weight, fasting blood glucose level, lipid level, insulin, and free fatty acid) and other parameters involving liver toxicity were measured with commercial kits and immunohistochemical method. Comparative studies on pharmacology showed that the crude extracts possess higher efficacy on hypoglycemia and hypolipidemia, while wine-processing products exhibit better effects on liver preservation. Our data suggested that wine processing was recommended when CF was used for protecting the liver; however, crude products should be used as antidiabetic drugs. |
url |
http://dx.doi.org/10.1155/2019/3986964 |
work_keys_str_mv |
AT huailongbi comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT douniu comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT chenguo comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT jiali comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT xuechen comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT yuanzhang comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT shaojunwang comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT jiqingbai comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT xingli comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects AT jiefangkang comparativestudyofcrudeandwineprocessingcornifructusonchemicalcompositionandantidiabeticeffects |
_version_ |
1725035099338047488 |
spelling |
doaj-b767b045077441b08ae7a29b2d081e172020-11-25T01:42:37ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/39869643986964Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic EffectsHuailong Bi0Dou Niu1Chen Guo2Jia Li3Xue Chen4Yuan Zhang5Shaojun Wang6Jiqing Bai7Xing Li8Jiefang Kang9Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaShaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, ChinaWine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, sweroside, and cornuside by UPLC was developed, and validating crude and wine-processing CF was done for the first time. Mice were randomly divided into the following groups and orally given different solutions for 4 weeks: normal group (NC, 0.4% (w/v) CMC-Na), model group (DM, 0.4% (w/v) CMC-Na), crude CF group (CP, 3.87 g/kg), and wine-processing CF group (PP, 3.87 g/kg) followed by HFD and multiple subcutaneous injection of STZ (40 mg/kg) to induce the diabetes model except the NC group. Biochemical indexes (body weight, fasting blood glucose level, lipid level, insulin, and free fatty acid) and other parameters involving liver toxicity were measured with commercial kits and immunohistochemical method. Comparative studies on pharmacology showed that the crude extracts possess higher efficacy on hypoglycemia and hypolipidemia, while wine-processing products exhibit better effects on liver preservation. Our data suggested that wine processing was recommended when CF was used for protecting the liver; however, crude products should be used as antidiabetic drugs.http://dx.doi.org/10.1155/2019/3986964 |