Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland

The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters we...

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Main Authors:	Stefan Grasl, Stefan Janik, Matthaeus C. Grasl, Johannes Pammer, Michael Formanek, Ilan Weinreb, Bayardo Perez-Ordonez, Andrew Hope, Ali Hosni, John R. de Almeida, Jon Irish, Ralph Gilbert, David P. Goldstein, Boban M. Erovic
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Journal of Clinical Medicine
Subjects:	acinic cell tumor parotid gland elective neck dissection
Online Access:	https://www.mdpi.com/2077-0383/8/9/1315

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spelling	doaj-b759be3d44b74b3c83a4a5df0c1350272020-11-24T20:52:50ZengMDPI AGJournal of Clinical Medicine2077-03832019-08-0189131510.3390/jcm8091315jcm8091315Nodal Metastases in Acinic Cell Carcinoma of the Parotid GlandStefan Grasl0Stefan Janik1Matthaeus C. Grasl2Johannes Pammer3Michael Formanek4Ilan Weinreb5Bayardo Perez-Ordonez6Andrew Hope7Ali Hosni8John R. de Almeida9Jon Irish10Ralph Gilbert11David P. Goldstein12Boban M. Erovic13Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, AustriaClinical Institute of Pathology, Medical University of Vienna, A-1097 Vienna, AustriaDepartment of Otorhinolaryngology and Phonetics, Hospital of St. John of God, 1020 Vienna, AustriaDepartment of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, CanadaDepartment of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, CanadaDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, CanadaDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, CanadaDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, CanadaDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, CanadaDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, CanadaDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, CanadaInstitute of Head and Neck Diseases, Evangelical Hospital Vienna, 1180 Vienna, AustriaThe objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (<i>p</i> = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69−44.01; <i>p</i> = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01−0.37; <i>p</i> = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02−0.59; <i>p</i> = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.https://www.mdpi.com/2077-0383/8/9/1315acinic cell tumorparotid glandelective neck dissection
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stefan Grasl Stefan Janik Matthaeus C. Grasl Johannes Pammer Michael Formanek Ilan Weinreb Bayardo Perez-Ordonez Andrew Hope Ali Hosni John R. de Almeida Jon Irish Ralph Gilbert David P. Goldstein Boban M. Erovic
spellingShingle	Stefan Grasl Stefan Janik Matthaeus C. Grasl Johannes Pammer Michael Formanek Ilan Weinreb Bayardo Perez-Ordonez Andrew Hope Ali Hosni John R. de Almeida Jon Irish Ralph Gilbert David P. Goldstein Boban M. Erovic Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland Journal of Clinical Medicine acinic cell tumor parotid gland elective neck dissection
author_facet	Stefan Grasl Stefan Janik Matthaeus C. Grasl Johannes Pammer Michael Formanek Ilan Weinreb Bayardo Perez-Ordonez Andrew Hope Ali Hosni John R. de Almeida Jon Irish Ralph Gilbert David P. Goldstein Boban M. Erovic
author_sort	Stefan Grasl
title	Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_short	Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_full	Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_fullStr	Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_full_unstemmed	Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_sort	nodal metastases in acinic cell carcinoma of the parotid gland
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2019-08-01
description	The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (<i>p</i> = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69−44.01; <i>p</i> = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01−0.37; <i>p</i> = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02−0.59; <i>p</i> = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.
topic	acinic cell tumor parotid gland elective neck dissection
url	https://www.mdpi.com/2077-0383/8/9/1315
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Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland

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