TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models

TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models

The ruthenium-based photosensitizer (PS) TLD1433 has completed a phase I clinical trial for photodynamic therapy (PDT) treatment of bladder cancer. Here, we investigated a possible repurposing of this drug for treatment of conjunctival melanoma (CM). CM is a rare but often deadly ocular cancer. The...

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Bibliographic Details
Main Authors: Quanchi Chen, Vadde Ramu, Yasmin Aydar, Arwin Groenewoud, Xue-Quan Zhou, Martine J. Jager, Houston Cole, Colin G. Cameron, Sherri A. McFarland, Sylvestre Bonnet, B. Ewa Snaar-Jagalska
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
photodynamic therapy
conjunctival melanoma
in vitro and in vivo models
application in cancer
zebrafish tumour model
Online Access:https://www.mdpi.com/2072-6694/12/3/587

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