Functions of PARylation in DNA Damage Repair Pathways

Functions of PARylation in DNA Damage Repair Pathways

Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs). This modification regulates a number of biological processes including chromatin reorganization, DNA damage response (DDR), transcrip...

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Bibliographic Details
Main Authors: Huiting Wei, Xiaochun Yu
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Poly ADP-ribosylation
PARPs
DNA damage response
PAR-binding modules
Ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022916300705

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