Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation.
Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function. The mechanism of initiator caspase activation has been generalized by the induced proximity model, which is thought to drive dimeriz...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-06-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1088972?pdf=render |