Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer

Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer

Metal complexes have been used to treat cancer since the discovery of cisplatin and its interaction with DNA in the 1960’s. Facing the resistance mechanisms against platinum salts and their side effects, safer therapeutic approaches have been sought through other metals, including ruthenium. In the...

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Bibliographic Details
Main Authors: Christian Gaiddon, Isabelle Gross, Xiangjun Meng, Marjorie Sidhoum, Georg Mellitzer, Benoit Romain, Jean-Batiste Delhorme, Aïna Venkatasamy, Alain C. Jung, Michel Pfeffer
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
ruthenium
osmium
cisplatin
chemotherapy
TP53
ER stress pathway
Online Access:https://www.mdpi.com/1420-3049/26/17/5386

Internet

https://www.mdpi.com/1420-3049/26/17/5386

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