Anthrax Toxin Characterization

Anthrax Toxin Characterization

The anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled. One anthrax protein, called protective antigen (PA), chaperones the two other toxins into human or animal cells and shields them from the body’s immun...

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Bibliographic Details
Main Authors: Jiří Patočka, Miroslav Špliňo
Format: Article
Language:English
Published: Karolinum Press 2002-01-01
Series:Acta Medica
Subjects:
Bacillus anthracis
Anthrax toxin
Structure
Mechanism of action
Online Access:https://actamedica.lfhk.cuni.cz/45/1/0003/
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spelling doaj-b72abed6d5a145b6b830412f78244fc12020-11-25T01:34:40ZengKarolinum PressActa Medica1211-42861805-96942002-01-014513510.14712/18059694.2019.49Anthrax Toxin CharacterizationJiří Patočka0Miroslav Špliňo1Purkyně Military Medical Academy, Department of Toxicology, Hradec Králové, Czech RepublicPurkyně Military Medical Academy, Department of Epidemiology, Hradec Králové, Czech RepublicThe anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled. One anthrax protein, called protective antigen (PA), chaperones the two other toxins into human or animal cells and shields them from the body’s immune system. The second, lethal factor (LF), destroys the white blood cells that hosts send in defence. The third toxin molecule, edema factor (EF), hijacks the signaling system in the body. This disrupts the energy balance of cells and leads to them accumulating fluid and complete destroy of cells.https://actamedica.lfhk.cuni.cz/45/1/0003/Bacillus anthracisAnthrax toxinStructureMechanism of action
collection DOAJ
language English
format Article
sources DOAJ
author Jiří Patočka
Miroslav Špliňo
spellingShingle Jiří Patočka
Miroslav Špliňo
Anthrax Toxin Characterization
Acta Medica
Bacillus anthracis
Anthrax toxin
Structure
Mechanism of action
author_facet Jiří Patočka
Miroslav Špliňo
author_sort Jiří Patočka
title Anthrax Toxin Characterization
title_short Anthrax Toxin Characterization
title_full Anthrax Toxin Characterization
title_fullStr Anthrax Toxin Characterization
title_full_unstemmed Anthrax Toxin Characterization
title_sort anthrax toxin characterization
publisher Karolinum Press
series Acta Medica
issn 1211-4286
1805-9694
publishDate 2002-01-01
description The anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled. One anthrax protein, called protective antigen (PA), chaperones the two other toxins into human or animal cells and shields them from the body’s immune system. The second, lethal factor (LF), destroys the white blood cells that hosts send in defence. The third toxin molecule, edema factor (EF), hijacks the signaling system in the body. This disrupts the energy balance of cells and leads to them accumulating fluid and complete destroy of cells.
topic Bacillus anthracis
Anthrax toxin
Structure
Mechanism of action
url https://actamedica.lfhk.cuni.cz/45/1/0003/
work_keys_str_mv AT jiripatocka anthraxtoxincharacterization
AT miroslavsplino anthraxtoxincharacterization
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