Effects of intravenous heparin on oxidation of fat

Effects of intravenous heparin on oxidation of fat

The intravenous injection of heparin to carbohydrate-fed rats results in an elevation of plasma free fatty acid levels and in a lowering of the respiratory quotient from 1.0 to 0.9. The injection of heparin simultaneously with palmitic acid-C14-labeled chylomicrons results in an elevation of the spe...

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Main Authors: A. Michajlik, J.H. Bragdon
Format: Article
Language:English
Published: Elsevier 1960-01-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520390787
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spelling doaj-b716aec8bd4349bd95c63ba0b0d1cd862021-04-23T06:11:06ZengElsevierJournal of Lipid Research0022-22751960-01-0112164166Effects of intravenous heparin on oxidation of fatA. Michajlik0J.H. Bragdon1Section on Metabolism, National Heart Institute, National Institutes of Health, Bethesda 14, MarylandSection on Metabolism, National Heart Institute, National Institutes of Health, Bethesda 14, MarylandThe intravenous injection of heparin to carbohydrate-fed rats results in an elevation of plasma free fatty acid levels and in a lowering of the respiratory quotient from 1.0 to 0.9. The injection of heparin simultaneously with palmitic acid-C14-labeled chylomicrons results in an elevation of the specific radioactivity of the expired CO2. These observations suggest that heparin causes an obligatory oxidation of fat, presumably through the release of free fatty acid from triglyceride.http://www.sciencedirect.com/science/article/pii/S0022227520390787
collection DOAJ
language English
format Article
sources DOAJ
author A. Michajlik
J.H. Bragdon
spellingShingle A. Michajlik
J.H. Bragdon
Effects of intravenous heparin on oxidation of fat
Journal of Lipid Research
author_facet A. Michajlik
J.H. Bragdon
author_sort A. Michajlik
title Effects of intravenous heparin on oxidation of fat
title_short Effects of intravenous heparin on oxidation of fat
title_full Effects of intravenous heparin on oxidation of fat
title_fullStr Effects of intravenous heparin on oxidation of fat
title_full_unstemmed Effects of intravenous heparin on oxidation of fat
title_sort effects of intravenous heparin on oxidation of fat
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 1960-01-01
description The intravenous injection of heparin to carbohydrate-fed rats results in an elevation of plasma free fatty acid levels and in a lowering of the respiratory quotient from 1.0 to 0.9. The injection of heparin simultaneously with palmitic acid-C14-labeled chylomicrons results in an elevation of the specific radioactivity of the expired CO2. These observations suggest that heparin causes an obligatory oxidation of fat, presumably through the release of free fatty acid from triglyceride.
url http://www.sciencedirect.com/science/article/pii/S0022227520390787
work_keys_str_mv AT amichajlik effectsofintravenousheparinonoxidationoffat
AT jhbragdon effectsofintravenousheparinonoxidationoffat
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