Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice

Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice

Abstract The anti-bone resorptive drugs denosumab, an anti-human-RANKL antibody, and zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, have recently been applied for treatment of pediatric patients with bone diseases, though details regarding their effects in growing children have yet to...

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Bibliographic Details
Main Authors: Motoki Isawa, Akiko Karakawa, Nobuhiro Sakai, Saki Nishina, Miku Kuritani, Masahiro Chatani, Takako Negishi-Koga, Masashi Sato, Mitsuko Inoue, Yukie Shimada, Masamichi Takami
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-56151-1

Internet

https://doi.org/10.1038/s41598-019-56151-1

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