Cancer-Associated Fibroblasts Accelerate Malignant Progression of Non-Small Cell Lung Cancer via Connexin 43-Formed Unidirectional Gap Junctional Intercellular Communication

Cancer-Associated Fibroblasts Accelerate Malignant Progression of Non-Small Cell Lung Cancer via Connexin 43-Formed Unidirectional Gap Junctional Intercellular Communication

Background/Aims: Gap junctions, which are assembled by connexins, can directly connect the cytoplasm of adjacent cells and enable gap junctional intercellular communication (GJIC) as well as metabolic coupling between neighboring cells. Here, we investigated the role of connexin 43 (Cx43) and its de...

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Bibliographic Details
Main Authors: Min Luo, Yanmei Luo, Naiquan Mao, Guolin Huang, Cuifang Teng, Hanlin Wang, Junwei Wu, Xiaoli Liao, Jie  Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Connexin 43
Unidirectional gap junctional intercellular communication
Cancer-associated fibroblasts
Non-small cell lung cancer
Metabolic coupling
Malignant progression
Online Access:https://www.karger.com/Article/FullText/495232

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