Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

Oncogenic KRAS mutations develop unique metabolic dependencies on nutrients to support tumor metabolism and cell proliferation. In particular, KRAS mutant cancer cells exploit amino acids (AAs) such as glutamine and leucine, to accelerate energy metabolism, redox balance through glutathione synthesi...

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Bibliographic Details
Main Authors: Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol‐Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Molecular Oncology
Subjects:
amino acid transporters
oncogene
SLC1A5/ASCT2
SLC38A2/SNAT2
SLC7A5/LAT1
solute carriers
Online Access:https://doi.org/10.1002/1878-0261.12999

Internet

https://doi.org/10.1002/1878-0261.12999

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