Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome

Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome

OBJECTIVE: To evaluate whether germline variants of the succinate dehydrogenase genes might be phenotypic modifiers in patients with multiple endocrine neoplasia type 2. Mutations of genes encoding subunits of the succinate dehydrogenase are associated with hereditary paraganglioma/pheochromocytoma...

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Bibliographic Details
Main Authors: Nikoletta Lendvai, Miklos Tóth, Zsuzsanna Valkusz, Gabriella Bekő, Nikolette Szücs, Éva Csajbók, Péter Igaz, Balázs Kriszt, Balázs Kovács, Károly Rácz, Attila Patócs
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2012-01-01
Series:Clinics
Subjects:
RET proto-oncogene
Succinate dehydrogenase subunit D
Medullary thyroid cancer
Pheochromocytoma
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001300015

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001300015

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