Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer.

Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer.

Bmi1 is overexpressed in a variety of human cancers including gastrointestinal cancer. The high expression level of Bmi1 protein is associated with poor prognosis of gastrointestinal cancer patients. On the other hand, tumor-associated macrophages (TAMs) contribute to tumor growth, invasion, and met...

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Bibliographic Details
Main Authors: Hidetaka Sugihara, Takatsugu Ishimoto, Masayuki Watanabe, Hiroshi Sawayama, Masaaki Iwatsuki, Yoshifumi Baba, Yoshihiro Komohara, Motohiro Takeya, Hideo Baba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842972?pdf=render

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