Exploring the RNA-Recognition Mechanism Using Supervised Molecular Dynamics (SuMD) Simulations: Toward a Rational Design for Ribonucleic-Targeting Molecules?

Exploring the RNA-Recognition Mechanism Using Supervised Molecular Dynamics (SuMD) Simulations: Toward a Rational Design for Ribonucleic-Targeting Molecules?

Although proteins have represented the molecular target of choice in the development of new drug candidates, the pharmaceutical importance of ribonucleic acids has gradually been growing. The increasing availability of structural information has brought to light the existence of peculiar three-dimen...

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Bibliographic Details
Main Authors: Maicol Bissaro, Mattia Sturlese, Stefano Moro
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Chemistry
Subjects:
nucleic acids
RNA
SMIRNA
molecular recognition
molecular dynamics (MD)
supervised molecular dynamics (SuMD)
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00107/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00107/full

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