MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice.

MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice.

MIR233 is genetically or epigenetically silenced in a subset of acute myeloid leukemia (AML). MIR223 is normally expressed throughout myeloid differentiation and highly expressed in hematopoietic stem cells (HSCs). However, the contribution of MIR223 loss to leukemic transformation and HSC function...

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Bibliographic Details
Main Authors: Maria C Trissal, Ricardo A DeMoya, Amy P Schmidt, Daniel C Link
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368818?pdf=render

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