GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

Summary: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth differentiation factor 15 (GDF15), a stress response cytokine...

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Bibliographic Details
Main Authors: David Aguilar-Recarte, Emma Barroso, Anna Gumà, Javier Pizarro-Delgado, Lucía Peña, Maria Ruart, Xavier Palomer, Walter Wahli, Manuel Vázquez-Carrera
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
GDF15
PPARβ/δ
AMPK
p53
glucose tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009293

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http://www.sciencedirect.com/science/article/pii/S2211124721009293

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