STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to ant...

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Main Authors:	Jung-Mao Hsu, Weiya Xia, Yi-Hsin Hsu, Li-Chuan Chan, Wen-Hsuan Yu, Jong-Ho Cha, Chun-Te Chen, Hsin-Wei Liao, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Chia-Wei Li, Seung-Oe Lim, Shih-Shin Chang, Yi-Chun Chen, Guo-xin Ren, Mien-Chie Hung
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04313-6

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spelling	doaj-b6e5e0697fa048aeb6392035c75e7d852021-05-11T10:04:47ZengNature Publishing GroupNature Communications2041-17232018-05-019111710.1038/s41467-018-04313-6STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasionJung-Mao Hsu0Weiya Xia1Yi-Hsin Hsu2Li-Chuan Chan3Wen-Hsuan Yu4Jong-Ho Cha5Chun-Te Chen6Hsin-Wei Liao7Chu-Wei Kuo8Kay-Hooi Khoo9Jennifer L. Hsu10Chia-Wei Li11Seung-Oe Lim12Shih-Shin Chang13Yi-Chun Chen14Guo-xin Ren15Mien-Chie Hung16Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Oral and Maxillofacial, Head and Neck Oncology, Affiliated 9th People’s Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterPD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to anti-Tim3-therapy.https://doi.org/10.1038/s41467-018-04313-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jung-Mao Hsu Weiya Xia Yi-Hsin Hsu Li-Chuan Chan Wen-Hsuan Yu Jong-Ho Cha Chun-Te Chen Hsin-Wei Liao Chu-Wei Kuo Kay-Hooi Khoo Jennifer L. Hsu Chia-Wei Li Seung-Oe Lim Shih-Shin Chang Yi-Chun Chen Guo-xin Ren Mien-Chie Hung
spellingShingle	Jung-Mao Hsu Weiya Xia Yi-Hsin Hsu Li-Chuan Chan Wen-Hsuan Yu Jong-Ho Cha Chun-Te Chen Hsin-Wei Liao Chu-Wei Kuo Kay-Hooi Khoo Jennifer L. Hsu Chia-Wei Li Seung-Oe Lim Shih-Shin Chang Yi-Chun Chen Guo-xin Ren Mien-Chie Hung STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion Nature Communications
author_facet	Jung-Mao Hsu Weiya Xia Yi-Hsin Hsu Li-Chuan Chan Wen-Hsuan Yu Jong-Ho Cha Chun-Te Chen Hsin-Wei Liao Chu-Wei Kuo Kay-Hooi Khoo Jennifer L. Hsu Chia-Wei Li Seung-Oe Lim Shih-Shin Chang Yi-Chun Chen Guo-xin Ren Mien-Chie Hung
author_sort	Jung-Mao Hsu
title	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_short	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_full	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_fullStr	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_full_unstemmed	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_sort	stt3-dependent pd-l1 accumulation on cancer stem cells promotes immune evasion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to anti-Tim3-therapy.
url	https://doi.org/10.1038/s41467-018-04313-6
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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

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