| Summary: | Many individuals seek to control their body weight while simultaneously being able to satisfy their appetite. It has been reported that polyphenols can restrain energy harvest by regulating gut microbiota. This study presents the co-action of a high-fat diet and polyphenols (quercetin and catechin) on rats' gut microbiota and growth. Results show that the rats that received catechin supplement had the lowest average body weight (P < 0.05). Supplement of catechin, but not quercetin, distinctly altered the composition and down-regulated the diversity of rats' gut microbiota without changing Firmicutes/Bacteroidetes ratio. However, almost all serum biochemical indices were not significantly altered due to catechin. In conclusion, supplementing a high-fat diet with catechin can control BW by inhibiting one's appetite. Furthermore, quercetin supplement did not change BW; however, it did result in better serum indices, such as TG. Thus, supplementing with a mixture of various polyphenols may be a better health choice.
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