Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives

Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives

The Plasmodium falciparum cysteine protease falcipain-2, one of the most promising targets for antimalarial drug design, plays a key role in parasite survival as a major peptide hydrolase within the hemoglobin degradation pathway. In this work, a series of novel dihydroartemisinin derivatives based...

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Bibliographic Details
Main Authors:	Jian Wang, Jin Huang, Chun Guo, Wei Luo, Yang Liu, Weiqiang Lu, Kunqiang Cui
Format:	Article
Language:	English
Published:	MDPI AG 2011-05-01
Series:	Molecules
Subjects:	falcipain-2 inhibitors dihydroartemisinin derivatives inhibition activity molecular docking studies SARs
Online Access:	http://www.mdpi.com/1420-3049/16/6/4527/

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