An unexpected protein interaction promotes drug resistance in leukemia

An unexpected protein interaction promotes drug resistance in leukemia

ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores...

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Main Authors: Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01678-y
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spelling doaj-b6c8588bcf0a40118828477b2bfbf11e2021-05-11T07:30:21ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-01678-yAn unexpected protein interaction promotes drug resistance in leukemiaAaron Pitre0Yubin Ge1Wenwei Lin2Yao Wang3Yu Fukuda4Jamshid Temirov5Aaron H. Phillips6Jennifer L. Peters7Yiping Fan8Jing Ma9Amanda Nourse10Chandrima Sinha11Hai Lin12Richard Kriwacki13James R. Downing14Tanja A. Gruber15Victoria E. Centonze16Anjaparavanda P. Naren17Taosheng Chen18John D. Schuetz19Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)Department of Oncology and the Molecular Therapeutics Program of the Barbara Ann Karmanos Cancer Institute, Wayne State University School of MedicineDepartment of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital (SJCRH)Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)Cell and Tissue Imaging Center, St. Jude Children’s Research Hospital (SJCRH)Department of Structural Biology, St. Jude Children’s Research Hospital (SJCRH)Cell and Tissue Imaging Center, St. Jude Children’s Research Hospital (SJCRH)Department of Computational Biology, St. Jude Children’s Research Hospital (SJCRH)Department of Pathology, St. Jude Children’s Research Hospital (SJCRH)Molecular Interaction Analysis Shared Resource, St. Jude Children’s Research Hospital (SJCRH)Department of Physiology, University of Tennessee Health Sciences CenterDepartment of Hematology and Oncology, The First Hospital of Jilin UniversityDepartment of Structural Biology, St. Jude Children’s Research Hospital (SJCRH)Department of Pathology, St. Jude Children’s Research Hospital (SJCRH)Department of Pathology, St. Jude Children’s Research Hospital (SJCRH)Cell and Tissue Imaging Center, St. Jude Children’s Research Hospital (SJCRH)Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDepartment of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital (SJCRH)Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.https://doi.org/10.1038/s41467-017-01678-y
collection DOAJ
language English
format Article
sources DOAJ
author Aaron Pitre
Yubin Ge
Wenwei Lin
Yao Wang
Yu Fukuda
Jamshid Temirov
Aaron H. Phillips
Jennifer L. Peters
Yiping Fan
Jing Ma
Amanda Nourse
Chandrima Sinha
Hai Lin
Richard Kriwacki
James R. Downing
Tanja A. Gruber
Victoria E. Centonze
Anjaparavanda P. Naren
Taosheng Chen
John D. Schuetz
spellingShingle Aaron Pitre
Yubin Ge
Wenwei Lin
Yao Wang
Yu Fukuda
Jamshid Temirov
Aaron H. Phillips
Jennifer L. Peters
Yiping Fan
Jing Ma
Amanda Nourse
Chandrima Sinha
Hai Lin
Richard Kriwacki
James R. Downing
Tanja A. Gruber
Victoria E. Centonze
Anjaparavanda P. Naren
Taosheng Chen
John D. Schuetz
An unexpected protein interaction promotes drug resistance in leukemia
Nature Communications
author_facet Aaron Pitre
Yubin Ge
Wenwei Lin
Yao Wang
Yu Fukuda
Jamshid Temirov
Aaron H. Phillips
Jennifer L. Peters
Yiping Fan
Jing Ma
Amanda Nourse
Chandrima Sinha
Hai Lin
Richard Kriwacki
James R. Downing
Tanja A. Gruber
Victoria E. Centonze
Anjaparavanda P. Naren
Taosheng Chen
John D. Schuetz
author_sort Aaron Pitre
title An unexpected protein interaction promotes drug resistance in leukemia
title_short An unexpected protein interaction promotes drug resistance in leukemia
title_full An unexpected protein interaction promotes drug resistance in leukemia
title_fullStr An unexpected protein interaction promotes drug resistance in leukemia
title_full_unstemmed An unexpected protein interaction promotes drug resistance in leukemia
title_sort unexpected protein interaction promotes drug resistance in leukemia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.
url https://doi.org/10.1038/s41467-017-01678-y
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