Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies

Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies

ObjectiveTo first describe and estimate the potential pathogenic role of Ig4 autoantibodies in complement-mediated thrombotic microangiopathy (TMA) in a patient with IgG4-related disease (IgG4-RD).MethodsThis study is a case report presenting a retrospective review of the patient’s medical chart. Pl...

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Bibliographic Details
Main Authors:	Gautier Breville, Ido Zamberg, Salima Sadallah, Caroline Stephan, Belen Ponte, Jörg D. Seebach
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Immunology
Subjects:	thrombotic microangiopathy atypical hemolytic uremic syndrome IgG4-related disease antibodies complement factor H-related protein complement factor H
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.604759/full

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