CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

p21<sup>Waf/CIP1</sup> is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell c...

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Bibliographic Details
Main Authors: Sabrina Florencia Mansilla, María Belén de la Vega, Nicolás Luis Calzetta, Sebastián Omar Siri, Vanesa Gottifredi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
p21CDKN1A
CDK
PCNA
TLS
S phase
DNA replication
Online Access:https://www.mdpi.com/2073-4425/11/6/593

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