Impact of central and peripheral estrogen treatment on anxiety and depression phenotypes in a mouse model of postmenopausal obesity.

Obesity and diabetes increase the risk of depression, and the incidence of these conditions increases rapidly after menopause, but few animal models of postmenopausal obesity have been available. We developed a mouse model of postmenopausal obesity that exhibited anxiety and depressive phenotypes in...

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Bibliographic Details
Main Authors: Tsutomu Wada, Azusa Sameshima, Rika Yonezawa, Mayuko Morita, Kanae Sawakawa, Hiroshi Tsuneki, Toshiyasu Sasaoka, Shigeru Saito
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209859

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