FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS

FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS

Abstract. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes. We have revealed some relationships and pecu...

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Main Author: T. V. Saprina
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
autoimmune thyroiditis
graves disease
il-2
il-4
lymphocytes
Online Access:https://www.mimmun.ru/mimmun/article/view/523
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spelling doaj-b6b2b405d6fe4b9fa19d3801886388332021-07-29T09:02:26ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-01144-536537210.15789/1563-0625-2012-4-5-365-372520FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERST. V. Saprina0Научно-образовательный центр молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Минздравсоцразвития России, г. ТомскAbstract. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes. We have revealed some relationships and peculiarities of the immune state deviations in these clinical disorders. We evaluated interrelations between some indexes of IL-2 and IL-4 production/reception, and functional parameters of thyroid gland in the patients. Multi-directional effects of interleukin-2 upon thyroid function were revealed, e.g., reduced cell proliferation levels and decreased functional activity of thyrocytes in autoimmune Hashimoto’s thyroiditis, as well as stimulation of proliferation and hormone production by thyrocytes in Graves’ disease.https://www.mimmun.ru/mimmun/article/view/523autoimmune thyroiditisgraves diseaseil-2il-4lymphocytes
collection DOAJ
language Russian
format Article
sources DOAJ
author T. V. Saprina
spellingShingle T. V. Saprina
FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
Medicinskaâ Immunologiâ
autoimmune thyroiditis
graves disease
il-2
il-4
lymphocytes
author_facet T. V. Saprina
author_sort T. V. Saprina
title FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_short FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_full FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_fullStr FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_full_unstemmed FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_sort features of interleukin-2 and interleukin-4 production and reception in autoimmune thyroid disorders
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2014-07-01
description Abstract. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes. We have revealed some relationships and peculiarities of the immune state deviations in these clinical disorders. We evaluated interrelations between some indexes of IL-2 and IL-4 production/reception, and functional parameters of thyroid gland in the patients. Multi-directional effects of interleukin-2 upon thyroid function were revealed, e.g., reduced cell proliferation levels and decreased functional activity of thyrocytes in autoimmune Hashimoto’s thyroiditis, as well as stimulation of proliferation and hormone production by thyrocytes in Graves’ disease.
topic autoimmune thyroiditis
graves disease
il-2
il-4
lymphocytes
url https://www.mimmun.ru/mimmun/article/view/523
work_keys_str_mv AT tvsaprina featuresofinterleukin2andinterleukin4productionandreceptioninautoimmunethyroiddisorders
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