Morphological and functional changes in innervation of a fast forelimb muscle in SOD1-G85R mice

Morphological and functional changes in innervation of a fast forelimb muscle in SOD1-G85R mice

Muscle endplates become denervated in mice that express mutations of human superoxide dismutase 1 (hSOD1), models of familial amyotrophic lateral sclerosis. This denervation is especially marked in fast limb muscles, and precedes death of motor neuron somata. This study used mice that expressed yell...

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Bibliographic Details
Main Authors: Khanh T. Nguyen, Zhongsheng Zhang, Ellen F. Barrett, Gavriel David
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
Familial amyotrophic lateral sclerosis
Superoxide dismutase 1 G85R
Yellow fluorescent protein
Motor nerve terminal
Neuromuscular junction
Denervation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002525

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http://www.sciencedirect.com/science/article/pii/S0969996112002525

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