The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time

Hormone replacement therapy (HRT) for dry eye syndrome (DES) is controversial in clinical practice. The goal of this study was to review relevant studies and analyze the pooled data to determine whether HRT is effective for DES. In this study, a literature search of PubMed, Embase, and Cochrane dat...

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Main Authors:	Yanhong Feng, Gang Feng, Shuli Peng, Hui Li
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Journal of Ophthalmology
Online Access:	http://dx.doi.org/10.1155/2015/420302

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spelling	doaj-b6b0f88bbca44d0ca3aecd19163c5aa62020-11-24T23:21:10ZengHindawi LimitedJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/420302420302The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up TimeYanhong Feng0Gang Feng1Shuli Peng2Hui Li3First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121000, ChinaFirst Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121000, ChinaDepartment of Ophthalmology, Huludao Central Hospital, Huludao, Liaoning 121000, ChinaDepartment of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaHormone replacement therapy (HRT) for dry eye syndrome (DES) is controversial in clinical practice. The goal of this study was to review relevant studies and analyze the pooled data to determine whether HRT is effective for DES. In this study, a literature search of PubMed, Embase, and Cochrane databases up to May 2015 was performed, with the search restricted to English language publications. The studies were screened after reading the abstract and full text. Only studies related to the effect of HRT on DES were included in the meta-analysis. Results of Schirmer tests with and without anesthetics and tear break-up time (BUT) values data were extracted and entered into RevMan software to meta-analyze the overall effect of HRT on DES. A total of 43 studies were identified, and 21 of these studies were found to be related to the effect of HRT on DES. Ultimately, 5 studies were included in the final meta-analysis. The pooled results revealed that HRT can affect Schirmer test results without anesthetics but does not affect Schirmer test results with anesthetics and BUT. The results indicate that HRT might improve DES symptoms when measuring basal tear production without anesthesia.http://dx.doi.org/10.1155/2015/420302
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yanhong Feng Gang Feng Shuli Peng Hui Li
spellingShingle	Yanhong Feng Gang Feng Shuli Peng Hui Li The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time Journal of Ophthalmology
author_facet	Yanhong Feng Gang Feng Shuli Peng Hui Li
author_sort	Yanhong Feng
title	The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time
title_short	The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time
title_full	The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time
title_fullStr	The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time
title_full_unstemmed	The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time
title_sort	effect of hormone replacement therapy on dry eye syndrome evaluated with schirmer test and break-up time
publisher	Hindawi Limited
series	Journal of Ophthalmology
issn	2090-004X 2090-0058
publishDate	2015-01-01
description	Hormone replacement therapy (HRT) for dry eye syndrome (DES) is controversial in clinical practice. The goal of this study was to review relevant studies and analyze the pooled data to determine whether HRT is effective for DES. In this study, a literature search of PubMed, Embase, and Cochrane databases up to May 2015 was performed, with the search restricted to English language publications. The studies were screened after reading the abstract and full text. Only studies related to the effect of HRT on DES were included in the meta-analysis. Results of Schirmer tests with and without anesthetics and tear break-up time (BUT) values data were extracted and entered into RevMan software to meta-analyze the overall effect of HRT on DES. A total of 43 studies were identified, and 21 of these studies were found to be related to the effect of HRT on DES. Ultimately, 5 studies were included in the final meta-analysis. The pooled results revealed that HRT can affect Schirmer test results without anesthetics but does not affect Schirmer test results with anesthetics and BUT. The results indicate that HRT might improve DES symptoms when measuring basal tear production without anesthesia.
url	http://dx.doi.org/10.1155/2015/420302
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The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time

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