MHC class I cross-presentation by Dendritic Cells counteracts viral immune evasion

MHC class I cross-presentation by Dendritic Cells counteracts viral immune evasion

DCs very potently activate CD8+ T cells specific for viral peptides bound to MHC class I molecules. However, many viruses have evolved immune evasion mechanisms, which inactivate infected DCs and might reduce priming of T cells. Then MHC class I cross-presentation of exogenous viral Ag by non-infect...

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Bibliographic Details
Main Authors: Katrin eNopora, Caroline Andree Bernhard, Christine eRied, Alejandro A Castello, Kenneth M Murphy, Peggy eMarconi, Ulrich Helmut Koszinowski, Thomas eBrocker
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Immunology
Subjects:
Antigen Presentation
Cross-Priming
Dendritic Cells
Immune Evasion
Virus infection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00348/full

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