Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.

Considerable controversy exists regarding the exact nature of the molecular mechanism of interfacial activation, a process by which most lipases achieve maximum catalytic activity upon adsorption to an oil water interface. X-ray crystallographic studies show that lipases contain buried active center...

Full description

Bibliographic Details
Main Authors: U Derewenda, L Swenson, Y Wei, R Green, P M Kobos, R Joerger, M J Haas, Z S Derewenda
Format: Article
Language:English
Published: Elsevier 1994-03-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520412039