MAT2A as Key Regulator and Therapeutic Target in <i>MLL</i>r Leukemogenesis

MAT2A as Key Regulator and Therapeutic Target in <i>MLL</i>r Leukemogenesis

Epigenetic dysregulation plays a pivotal role in mixed-lineage leukemia (<i>MLL)</i> pathogenesis, therefore serving as a suitable therapeutic target. S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A),...

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Bibliographic Details
Main Authors: Kathy-Ann Secker, Bianca Bloechl, Hildegard Keppeler, Silke Duerr-Stoerzer, Hannes Schmid, Dominik Schneidawind, Johan Jeong, Thomas Hentrich, Julia M. Schulze-Hentrich, Corina Schneidawind
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
<i>MLL</i>-rearranged leukemia
MAT2A
CRISPR/Cas9
pharmacological study
Online Access:https://www.mdpi.com/2072-6694/12/5/1342

Internet

https://www.mdpi.com/2072-6694/12/5/1342

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