Regulation of lipid signaling by diacylglycerol kinases during T cell development and function

Regulation of lipid signaling by diacylglycerol kinases during T cell development and function

Diacylglycerol (DAG) and phosphatidic acid (PA) are bioactive lipids synthesized when the T cell receptor binds to a cognate peptide-MHC complex. DAG triggers signaling by recruiting RasGRP1, PKCθ and other effectors, whereas PA binds to effector molecules that include mTOR, SHP1 and Raf1. While DAG...

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Bibliographic Details
Main Authors: Sruti eKrishna, Xiao-Ping eZhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Immunology
Subjects:
Diacylglycerol Kinase
Macrophages
Mast Cells
T cell receptor
T cell activation
T cell development
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00178/full

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