Regulation of lipid signaling by diacylglycerol kinases during T cell development and function
Diacylglycerol (DAG) and phosphatidic acid (PA) are bioactive lipids synthesized when the T cell receptor binds to a cognate peptide-MHC complex. DAG triggers signaling by recruiting RasGRP1, PKCθ and other effectors, whereas PA binds to effector molecules that include mTOR, SHP1 and Raf1. While DAG...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00178/full |