Genetic and chemical modifiers of a CUG toxicity model in Drosophila.

Genetic and chemical modifiers of a CUG toxicity model in Drosophila.

Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context...

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Bibliographic Details
Main Authors: Amparo Garcia-Lopez, Lidon Monferrer, Irma Garcia-Alcover, Marta Vicente-Crespo, M Carmen Alvarez-Abril, Ruben D Artero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2220037?pdf=render

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http://europepmc.org/articles/PMC2220037?pdf=render

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