A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin

A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin

Salt-induced kinase 2 (SIK2) is a serine-threonine kinase that regulates centrosome splitting, activation of PI3 kinase and phosphorylation of class IIa HDACs, affecting gene expression. Previously, we found that inhibition of SIK2 enhanced sensitivity of ovarian cancer cells to paclitaxel. Carbopla...

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Bibliographic Details
Main Authors: Dengxuan Fan, Hailing Yang, Weiqun Mao, Philip J. Rask, Lan Pang, Congjian Xu, Hariprasad Vankayalapat, Ahmed A. Ahmed, Robert C. Bast, Zhen Lu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
salt inducible kinase 2 (SIK2)
PARP inhibitor
carboplatin sensitivity
γ-H2AX
comet assay
apoptosis
Online Access:https://www.mdpi.com/2072-6694/13/3/446

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