Alternative Leprosy Treatment Using Rifampicin Ofloxacin Minocycline (ROM) Regimen – Two Case Reports

• Main Authors: Widjaja Yohanes, Djawad Khairuddin, Amin Saffruddin, Djamaluddin Widyawati, Kadir Dirmawati, Muchtar Sri V.
• Format: Article
• Language: English
• Published: Sciendo 2019-09-01
• Series: Serbian Journal of Dermatology and Venereology
• Subjects: cranial nerve diseases; herpes zoster oticus; neuritis; signs and symptoms; diagnosis; antiviral agents; rare diseases
• Online Access: https://doi.org/10.2478/sjdv-2019-0013

Introduction. Leprosy is a disease that predominantly affects the skin and peripheral nerves, resulting in neuropathy and associated long-term consequences, including deformities and disabilities. According to the WHO classification, there are two categories of leprosy, paucibacillary (PB) and multibacillary (MB). The standard treatment for leprosy employs the use of WHO MDT (Multi Drug Treatment) regimen, despite its multiple downsides such as clofazimine-induced pigmentation, dapsone-induced haematological adverse effects, poor compliance due to long therapy duration, drug resistance, and relapse. Multiple studies and case reports using ROM regimen have reported satisfactory results. Nevertheless, there are still insufficient data to elucidate the optimum dosage and duration of ROM regimen as an alternative treatment for leprosy. Previous experience from our institution revealed that ROM regimen given three times weekly resulted in a satisfactory outcome.