HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway

HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway

Abstract Background Endothelial injury is one of the predominant pathophysiological characteristics of sepsis and is the major cause of sepsis-induced multiple organ failure. Endothelial pyroptosis is a fatal mechanism of endothelial injury in sepsis, and specific, effective therapies are lacking. A...

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Bibliographic Details
Main Authors: Fei Peng, Wei Chang, Qin Sun, Xinyi Xu, Jianfeng Xie, Haibo Qiu, Yi Yang
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Respiratory Research
Subjects:
Sepsis
Endothelial injury
Pyroptosis
HGF
mTOR
Mitochondria physiology
Online Access:http://link.springer.com/article/10.1186/s12931-020-01480-3

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