Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies is to recognize overexpressed or specific tumor antigens and initiate either direct F(ab′)2-mediated tumor cel...

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Bibliographic Details
Main Authors: Arianne M. Brandsma, Sina Bondza, Mitchell Evers, Rosanne Koutstaal, Maaike Nederend, J. H. Marco Jansen, Thies Rösner, Thomas Valerius, Jeanette H. W. Leusen, Toine ten Broeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
IgA
immunotherapy
neutrophil
ADCC
cancer
Fc alpha receptor I
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00704/full

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