Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease

Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease

Protein synthesis and protein degradation are highly regulated cellular processes that are essential to maintaining cell viability. Numerous studies now indicate that protein synthesis and protein degradation are significantly altered in Alzheimer's disease (AD), with impairments in these two p...

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Main Author: Jeffrey N. Keller
Format: Article
Language:English
Published: Hindawi Limited 2006-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/JBB/2006/12129
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spelling doaj-b682a74fd57d4371a427bd21f60221502020-11-25T02:11:49ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512006-01-01200610.1155/JBB/2006/1212912129Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's DiseaseJeffrey N. Keller0Anatomy and Neurobiology, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USAProtein synthesis and protein degradation are highly regulated cellular processes that are essential to maintaining cell viability. Numerous studies now indicate that protein synthesis and protein degradation are significantly altered in Alzheimer's disease (AD), with impairments in these two processes potentially contributing to AD pathogenesis. Alterations in steady state protein regulation may be a particularly important factor in regulating whether cells maintain homeostasis in response to oxidative damage, or conversely whether oxidative stress is induced by oxidative damage. The focus of this review is to discuss recent findings on each of these topics, and to discuss their importance to the onset and progression of AD.http://dx.doi.org/10.1155/JBB/2006/12129
collection DOAJ
language English
format Article
sources DOAJ
author Jeffrey N. Keller
spellingShingle Jeffrey N. Keller
Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease
Journal of Biomedicine and Biotechnology
author_facet Jeffrey N. Keller
author_sort Jeffrey N. Keller
title Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease
title_short Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease
title_full Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease
title_fullStr Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease
title_full_unstemmed Interplay Between Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimer's Disease
title_sort interplay between oxidative damage, protein synthesis, and protein degradation in alzheimer's disease
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2006-01-01
description Protein synthesis and protein degradation are highly regulated cellular processes that are essential to maintaining cell viability. Numerous studies now indicate that protein synthesis and protein degradation are significantly altered in Alzheimer's disease (AD), with impairments in these two processes potentially contributing to AD pathogenesis. Alterations in steady state protein regulation may be a particularly important factor in regulating whether cells maintain homeostasis in response to oxidative damage, or conversely whether oxidative stress is induced by oxidative damage. The focus of this review is to discuss recent findings on each of these topics, and to discuss their importance to the onset and progression of AD.
url http://dx.doi.org/10.1155/JBB/2006/12129
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