The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel

The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel

Clinical and experimental results with inhaled sodium bicarbonate as an adjuvant therapy in cystic fibrosis (CF) are promising due to its mucolytic and bacteriostatic properties, but its direct effect has not been studied on respiratory epithelial cells. Our aim was to establish and characterize co-...

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Bibliographic Details
Main Authors: Ilona Gróf, Alexandra Bocsik, András Harazin, Ana Raquel Santa-Maria, Gaszton Vizsnyiczai, Lilla Barna, Lóránd Kiss, Gabriella Fűr, Zoltán Rakonczay, Jr., Rita Ambrus, Piroska Szabó-Révész, Fabien Gosselet, Pongsiri Jaikumpun, Hajnalka Szabó, Ákos Zsembery, Mária A. Deli
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
bronchial epithelial cells
CFTR channel
cystic fibrosis
cytokine
impedance kinetics
permeability
Online Access:https://www.mdpi.com/1422-0067/21/11/4024

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