Impacts of anti‐inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation

Impacts of anti‐inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation

Abstract Chronic obstructive pulmonary disease (COPD) often tends to respond poorly to glucocorticoid (GC) therapy. Reduced Histone deacetylase‐2 (HDAC‐2) activity is an important mechanism behind this GC insensitivity. In this study, we investigated the effects of three phosphodiesterase inhibitors...

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Bibliographic Details
Main Authors: Xiao‐Fang Zheng, Dan‐Dan Chen, Xiao‐Ling Zhu, Jehane Michael Le Grange, Lu‐Qian Zhou, Jin‐Nong Zhang
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Pharmacology Research & Perspectives
Subjects:
cigarette smoke
histone deacetylase‐2
lung inflammation
phosphodiesterase inhibitors
Online Access:https://doi.org/10.1002/prp2.840

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