Impact of Viral Activators and Epigenetic Regulators on HIV-1 LTRs Containing Naturally Occurring Single Nucleotide Polymorphisms

Impact of Viral Activators and Epigenetic Regulators on HIV-1 LTRs Containing Naturally Occurring Single Nucleotide Polymorphisms

Following human immunodeficiency virus type 1 (HIV-1) integration into host cell DNA, the viral promoter can become transcriptionally silent in the absence of appropriate signals and factors. HIV-1 gene expression is dependent on regulatory elements contained within the long terminal repeat (LTR) th...

Full description

Bibliographic Details
Main Authors:	Sonia Shah, Vanessa Pirrone, Aikaterini Alexaki, Michael R. Nonnemacher, Brian Wigdahl
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2015/320642

Similar Items

HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination.
by: Aikaterini Alexaki, et al.
Published: (2008-12-01)

Development of a Human Bone Marrow Progenitor Cell Line to Examine HIV-1 Susceptibility and LTR Activity
by: Wigdahl Brian, et al.
Published: (2005-12-01)

Epigenetic modifications of HIV proviral LTRs: potential targets for cure
by: Doerfler W, et al.
Published: (2012-05-01)

Characterization of C/EBP Binding Sites Downstream of the Transcriptional Start Site in the HIV-1 LTR
by: Wigdahl Brian, et al.
Published: (2005-12-01)

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.
by: Michael R Nonnemacher, et al.
Published: (2016-01-01)

Development of a Quantum Dot-based Assay System for Detection of Specific HIV-1 LTR Sequence Variants
by: Wigdahl Brian, et al.
Published: (2005-12-01)

Epigenetic Control of Human Endogenous Retrovirus Expression: Focus on Regulation of Long-Terminal Repeats (LTRs)
by: Tara P. Hurst, et al.
Published: (2017-05-01)

LTRs; Universal structure, detection and phylogeny
by: Blomberg Jonas, et al.
Published: (2009-09-01)

Evolutionary conservation of orthoretroviral long terminal repeats (LTRs) and ab initio detection of single LTRs in genomic data.
by: Farid Benachenhou, et al.
Published: (2009-01-01)

Gene looping between the viral LTRs is a hallmark of transcriptionally active HIV-1 and Mo-MLV proviral DNA
by: Giacca Mauro, et al.
Published: (2009-09-01)

cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells
by: Anupam Banerjee, et al.
Published: (2017-03-01)

Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site
by: Yujie Liu, et al.
Published: (2017-03-01)

Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease
by: Monique E Maubert, et al.
Published: (2016-01-01)

Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND
by: Jamie Marino, et al.
Published: (2020-06-01)

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage
by: Shah Sonia, et al.
Published: (2009-12-01)

Conserved structure and inferred evolutionary history of long terminal repeats (LTRs)
by: Benachenhou, Farid, et al.
Published: (2013)

LTRs of Endogenous Retroviruses as a Source of Tbx6 Binding Sites
by: Yukuto Yasuhiko, et al.
Published: (2017-06-01)

Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localization
by: Ferrucci Adriano, et al.
Published: (2011-08-01)

Biomarkers of HIV Susceptibility and Disease Progression
by: Vanessa Pirrone, et al.
Published: (2014-12-01)

Genetic variation continues to occur in well-controlled HIV-1-infected patients
by: W. Dampier, et al.
Published: (2015-12-01)

Opinion: Inhibition of Blood-Brain Barrier Repair as a Mechanism in HIV-1 Disease
by: Michael R. Nonnemacher, et al.
Published: (2017-04-01)

Use of HIV-1 LTR Sequence Variants as Prognostic Indicators of HIV Dementia
by: Wigdahl Brian, et al.
Published: (2005-12-01)

Region-specific Distribution of HIV-1 LTR C/EBP Site II Configurations in Demented and Non-demented Patients
by: Gartner Suzanne, et al.
Published: (2005-12-01)

Impact of Tat Genetic Variation on HIV-1 Disease
by: Luna Li, et al.
Published: (2012-01-01)

HIV-1 Tat Length: Comparative and Functional Considerations
by: Anthony R. Mele, et al.
Published: (2020-03-01)

Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
by: Pirrone Vanessa, et al.
Published: (2012-01-01)

Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation
by: Daniel R Fuentes, et al.
Published: (2018-08-01)

HIV-1 LTR Activity is Altered by Recruitment of Sp Transcription Factors During Monocytic Differentiation
by: Wigdahl Brian, et al.
Published: (2005-12-01)

Sequence-Specific Vpr Binding to HIV-1 LTR C/EBP Binding Sites and Adjacent Regions
by: Wigdahl Brian, et al.
Published: (2005-12-01)

The role of single nucleotide polymorphisms of cytokine genes in viral infections
by: Ćupić Maja, et al.
Published: (2014-01-01)

Parental LTRs are important in a construct of a stable and efficient replication-competent infectious molecular clone of HIV-1 CRF08_BC.
by: Qiwei Zhang, et al.
Published: (2012-01-01)

Enhancing Double-Beam Laser Tweezers Raman Spectroscopy (LTRS) for the Photochemical Study of Individual Airborne Microdroplets
by: Jovanny A. Gómez Castaño, et al.
Published: (2019-09-01)

Role of Human Endogenous Retroviral Long Terminal Repeats (LTRs) in Maintaining the Integrity of the Human Germ Line
by: Meihong Liu, et al.
Published: (2011-06-01)

Evidence for the existence of pathogenicity determinants in the Long Terminal Repeats (LTRs) of the Bovine Leukemia Virus (BLV) genome
by: Jones Leandro R, et al.
Published: (2011-06-01)

Utilizing the binding capacity of CRISPR/Cas9 to target the HIV-1 quasispecies
by: M. Nonnemacher, et al.
Published: (2015-12-01)

Nucleotide Metabolism Behind Epigenetics
by: Tamaki Suganuma, et al.
Published: (2021-08-01)

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection
by: Alexander G. Allen, et al.
Published: (2018-12-01)

Designing Safer CRISPR/Cas9 Therapeutics for HIV: Defining Factors That Regulate and Technologies Used to Detect Off-Target Editing
by: Neil T. Sullivan, et al.
Published: (2020-08-01)

Activation of LTRs from Different Human Endogenous Retrovirus (HERV) Families by the HTLV-1 Tax Protein and T-Cell Activators
by: Sebastien Landry, et al.
Published: (2011-11-01)

Human Endogenous Retroviruses (HERVs) and Mammalian Apparent LTRs Retrotransposons (MaLRs) Are Dynamically Modulated in Different Stages of Immunity
by: Maria Paola Pisano, et al.
Published: (2021-05-01)

Cannot write session to /tmp/vufind_sessions/sess_j19kcnpep4848n0k50lnr97vu2