Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents

Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents

Abstract Background Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randomly distributed. Although often indolent, these tumors are mostly chem...

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Bibliographic Details
Main Authors: Riccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria A. Pantaleo, Luigi M. Larocca
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Clinical Epigenetics
Subjects:
Gastrointestinal stromal tumors
Succinate dehydrogenase
O 6 -methylguanine DNA methyltransferase
DNA methylation
Wild-type GIST
Molecular diagnosis
Online Access:http://link.springer.com/article/10.1186/s13148-018-0594-9

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