Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice

Influenza virus surface glycoproteins represent the main targets of the immune system during infection and vaccination. Current influenza virus vaccines rely mostly on the hemagglutinin, requiring a close match between the vaccine and circulating strains. Recently, the neuraminidase (NA) has become...

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Bibliographic Details
Main Authors: Shirin Strohmeier, Juan Manuel Carreño, Ruhi Nichalle Brito, Florian Krammer
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Vaccines
Subjects:
N1
Online Access:https://www.mdpi.com/2076-393X/9/4/404